The Academic Department is the primary administrative division of faculty and course of study at Knox. There are eighteen academic departments in all.
 Departments, Courses of Study, and Faculty
These, however, do not represent all courses of study or faculty members at Knox. A number of interdisciplinary programs, for instance the Black Studies Program, have majors, minors, and courses of study of their own, generally of a nature which would not fit neatly into any one department. Most of the faculty forming the program committees for these are at least nominally rooted in one of the departments, but there are several exceptions for professors hired specifically for interdisciplinary programs (for instance in Black Studies, Environmental Science, and Biochemistry). Many academic departments have cooperating faculty from other departments or programs that will teach some courses (these are often cross-listed).
Often there are restrictions on the double-counting of courses between departmental and related interdisciplinary majors.
 Department Size
In order, the nine largest departments by faculty member count are: