U.S. Route 150

U.S. Route 150 (also known as Route 150 or Highway 150) is a 571 mile (919 km) long northwest-southeast United States highway, signed as east-west. It runs from U.S. Route 6 outside of Moline, Illinois to U.S. Route 25 in Mount Vernon, Kentucky.

In Galesburg, North Henderson Street and Main Street east of Henderson are cosigned as Highway 150.