First Street is a street in Galesburg. It runs east-west, and marks the 700 block south.
The street runs from its western end at Avenue B to its eastern end at Whiting Avenue. First Street has a large gap between Cedar Street and Seminary Street where it would cross the Burlington Northern Santa Fe mainline track. It has a second substantial gap between Day Street and Ohio Avenue (near Grand Avenue, between which part of the general right-of-way is taken up by Conger Street.
West of Broad Street it is called West First Street, and east of Broad Street it is called East First Street.
First Street forms the extreme southern edge of the Knox campus. Except in the area around Knox College, First Street is primarily residential.